On sunny summer days, powerboats pulling water-skiers zip across Georgia’s Lake Oconee, a reservoir located about an hour-and-a-half drive east of Atlanta. For those without a need for speed, fishing beckons.

Little do the lake’s visitors suspect that here lie the remains of a democratic institution that dates to around 500 A.D., more than 1,200 years before the founding of the U.S. Congress.

Reservoir waters, which flooded the Oconee Valley in 1979 after the construction of a nearby dam, partly cover remnants of a 1,500-year-old plaza once bordered by flat-topped earthen mounds and at least three large, circular buildings. Such structures, which have been linked to collective decision making, are known from other southeastern U.S. sites that date to as early as around 1,000 years ago.
At the Oconee site, called Cold Springs, artifacts were excavated before the valley became an aquatic playground. Now, new older-than-expected radiocarbon dates for those museum-held finds push back the origin of democratic institutions in the Americas several centuries, a team led by archaeologist Victor Thompson of the University of Georgia in Athens reported May 18 in American Antiquity.

Institutions such as these highlight a growing realization among archaeologists that early innovations in democratic rule emerged independently in many parts of the world. In specific, these findings add to evidence that Native American institutions devoted to promoting broad participation in political decisions emerged in various regions, including what’s now Canada, the United States and Mexico, long before 18th century Europeans took up the cause of democratic rule by the people.

That conclusion comes as no surprise to members of some Indigenous groups today. “Native people have been trying to convey for centuries that many communities have long-standing institutions [of] democratic and/or republican governance,” says University of Alberta archaeologist S. Margaret Spivey-Faulkner, a citizen of the Pee Dee Indian Nation of Beaver Creek in South Carolina.

Democratic innovations
Scholars have traditionally thought that democracy — generally referring to rule by the people, typically via elected representatives — originated around 2,500 years ago in Greece before spreading elsewhere in Europe. From that perspective, governments in the Americas that qualified as democratic didn’t exist before Europeans showed up.

That argument is as misguided as Christopher Columbus’ assumption that he had arrived in East India, not the Caribbean, in 1492, says archaeologist Jacob Holland-Lulewicz of Penn State, a coauthor of the Cold Springs report. Institutions that enabled representatives of large communities to govern collectively, without kings or ruling chiefs, characterized an unappreciated number of Indigenous societies long before the Italian explorer’s fateful first voyage, Holland-Lulewicz asserts.

In fact, collective decision-making arrangements that kept anyone from amassing too much power and wealth go back thousands, and probably tens of thousands of years in many parts of the world (SN: 11/9/21). The late anthropologist David Graeber and archaeologist David Wengrow of University College London describe evidence for that scenario in their 2021 book The Dawn of Everything.

But only in the last 20 years have archaeologists begun to take seriously claims that ancient forms of democratic rule existed. Scientific investigations informed by Indigenous partners will unveil past political realities “most of us in Indian country take for granted,” Spivey-Faulkner says.

Early consensus
Thompson’s Cold Springs project shows how such a partnership can work.

Ancestors of today’s Muscogee people erected Cold Springs structures within their original homelands, which once covered a big chunk of southeastern North America before the government-forced exodus west along the infamous Trail of Tears. Three members of the Muscogee Nation’s Department of Historic and Cultural Preservation in Okmulgee, Okla., all study coauthors, provided archaeologists with first-hand knowledge of Muscogee society. They emphasized to the researchers that present-day Muscogee councils where open debate informs consensus decisions carry on a tradition that goes back hundreds of generations.

A set of 44 new radiocarbon dates going back 1,500 years for material previously unearthed at the Georgia site, including what were likely interior posts from some structures, then made perfect sense. Earlier analyses in the 1970s of excavated pottery and six radiocarbon dates from two earthen mounds at Cold Springs suggested that they had been constructed at least 1,000 years ago.

Based on the new dating, Thompson’s team found that from roughly 500 A.D. to 700 A.D, Indigenous people at Cold Springs constructed not only earthen mounds but at least three council-style roundhouses — each 12 to 15 meters in diameter — and several smaller structures possibly used as temporary housing during meetings and ceremonies.

Small communities spread across the Oconee Valley formed tight-knit social networks called clans that gathered at council houses through the 1700s, Thompson’s group suspects. Spanish expeditions through the region from 1539 to 1543 did not cause those societies and their traditions to collapse, as has often been assumed, the researchers contend.
Excavations and radiocarbon dating at another Oconee Valley Muscogee site called Dyar support that view. A square ground connected to Dyar includes remains of a council house. Activity at the site began as early as 1350 and continued until as late as about 1670, or about 130 years after first encounters with the Spanish, Holland-Lulewicz and colleagues reported in the October 2020 American Antiquity.

Spanish historical accounts mistakenly assumed that powerful chiefs ran Indigenous communities in what have become known as chiefdoms. Many archaeologists have similarly, and just as wrongly, assumed that starting around 1,000 years ago, chiefs monopolized power in southeastern Native American villages, the scientists argue.

Today, members of the Muscogee (Creek) Nation in Oklahoma gather, sometimes by the hundreds or more, in circular structures called council houses to reach collective decisions about various community issues. Council houses typically border public square grounds. That’s a modern-day parallel to the story being told by the ancient architecture at Cold Springs.

“Muscogee councils are the longest-surviving democratic institution in the world,” Holland-Lulewicz says.

Indigenous influencers
Political consensus building by early Muscogee people didn’t occur in a vacuum. Across different regions of precontact North America, institutions that enabled broad participation in democratic governing characterized Indigenous societies that had no kings, central state governments or bureaucracies, Holland-Lulewicz and colleagues, report March 11 in Frontiers in Political Science.

The researchers dub such organizations keystone institutions. Representatives of households, communities, clans and religious societies, to name a few, met on equal ground at keystone institutions. Here, all manner of groups and organizations followed common rules to air their opinions and hammer out decisions about, say, distributing crops, organizing ceremonial events and resolving disputes.
For example, in the early 1600s, nations of the neighboring Wendat (Huron) and Haudenosaunee people in northeastern North America had formed political alliances known as confederacies, says coauthor Jennifer Birch, a University of Georgia archaeologist. Each population contained roughly 20,000 to 30,000 people. Despite their size, these confederacies did not hold elections in which individuals voted for representatives to a central governing body. Governing consisted of negotiations among intertwined segments of society orchestrated by clans, which claimed members across society.

Clans, in which membership was inherited through the female line, were — and still are — the social glue holding together Wendat (Huron) and Haudenosaunee politics. Residents of different villages or nations among, say, the Haudenosaunee, could belong to the same clan, creating a network of social ties. Excavations of Indigenous villages in eastern North America suggest that the earliest clans date to at least 3,000 years ago, Birch says.

Within clans, men and women held separate council meetings. Some councils addressed civil affairs. Others addressed military and foreign policy, typically after receiving counsel from senior clan women.

Clans controlled seats on confederacy councils of the Wendat and Haudenosaunee. But decisions hinged on negotiation and consensus. A member of a particular clan had no right to interfere in the affairs of any other clan. Members of villages or nations could either accept or reject a clan leader as their council representative. Clans could also join forces to pursue political or military objectives.

Some researchers, including Graeber and Wengrow, suspect a Wendat philosopher and statesman named Kandiaronk influenced ideas about democracy among Enlightenment thinkers in France and elsewhere. A 1703 book based on a French aristocrat’s conversations with Kandiaronk critiqued authoritarian European states and provided an Indigenous case for decentralized, representative governing.

Although Kandiaronk was a real person, it’s unclear whether that book presented his actual ideas or altered them to resemble what Europeans thought of as a “noble savage,” Birch says.

Researchers also debate whether writers of the U.S. Constitution were influenced by how the Haudenosaunee Confederacy distributed power among allied nations. Benjamin Franklin learned about Haudenosaunee politics during the 1740s and 1750s as colonists tried to establish treaties with the confederacy.

Colonists took selected political ideas from the Haudenosaunee Confederacy without grasping its underlying cultural concerns, says University of Alberta anthropological archaeologist Kisha Supernant, a member of an Indigenous population in Canada called Métis. The U.S. Constitution stresses individual freedoms, whereas the Indigenous system addresses collective responsibilities to manage the land, water, animals and people, she says.

Anti-Aztec equality
If democratic institutions are cultural experiments in power sharing, one of the most interesting examples emerged around 700 years ago in central Mexico.

In response to growing hostilities from surrounding allies of the Aztec Empire, a multi-ethnic confederation of villages called Tlaxcallan built a densely occupied city of the same name. When Spaniards arrived in 1519, they wrote of Tlaxcallan as a city without kings, rulers or wealthy elites.
Until the last decade, Mexican historians had argued that Tlaxcallan was a minor settlement, not a city. They dismissed historical Spanish accounts as exaggerations of the newcomers’ exploits.

Opinions changed after a team led by archaeologist Lane Fargher of Mexico’s Centro de Investigación y Estudios Avanzados del Instituto Polytécnico Nacional (Cinvestav del IPN) in Merida surveyed and mapped visible remains of Tlaxcallan structures from 2007 to 2010. Excavations followed from 2015 through 2018, revealing a much larger and denser settlement than previously suspected.

The ancient city covers a series of hilltops and hillsides, Fargher says. Large terraces carved out of hillsides supported houses, public structures, plazas, earthen mounds and roadways. Around 35,000 people inhabited an area of about 4.5 square kilometers in the early 1500s.

Artifacts recovered at plazas indicate that those open spaces hosted commercial, political and religious activities. Houses clustered around plazas. Even the largest residences were modest in size, not much larger than the smallest houses. Palaces of kings and political big shots in neighboring societies, including the Aztecs, dwarfed Tlaxcallan houses.
Excavations and Spanish accounts add up to a scenario in which all Tlaxcallan citizens could participate in governmental affairs. Anyone known to provide good advice on local issues could be elected by their neighbors in a residential district to a citywide ruling council, or senate, consisting of between 50 and 200 members. Council meetings were held at a civic-ceremonial center built on a hilltop about one kilometer from Tlaxcallan.

As many as 4,000 people attended council meetings regarding issues of utmost importance, such as launching military campaigns, Fargher says.

Those chosen for council positions had to endure a public ceremony in which they were stripped naked, shoved, hit and insulted as a reminder that they served the people. Political officials who accumulated too much wealth could be publicly punished, replaced or even killed.

Tlaxcallan wasn’t a social utopia. Women, for instance, had limited political power, possibly because the main route to government positions involved stints of military service. But in many ways, political participation at Tlaxcallan equaled or exceeded that documented for ancient Greek democracy, Fargher and colleagues reported March 29 in Frontiers of Political Science. Greeks from all walks of life gathered in public spaces to speak freely about political issues. But commoners and the poor could not hold the highest political offices. And again, women were excluded.

Good government
Tlaxcallan aligned itself with Spanish conquerors against their common Aztec enemy. Then in 1545, the Spanish divided the Tlaxcallan state into four fiefdoms, ending Tlaxcallan’s homegrown style of democratic rule.

The story of this fierce, equality-minded government illustrates the impermanence of political systems that broadly distribute power, Fargher says. Research on past societies worldwide “shows us how bad the human species is at building and maintaining democratic governments,” he contends.

Archaeologist Richard Blanton of Purdue University and colleagues, including Fargher, analyzed whether 30 premodern societies dating to as early as around 3,000 years ago displayed signs of “good government.” An overall score of government quality included evidence of systems for providing equal justice, fair taxation, control over political officials’ power and a political voice for all citizens.

Only eight societies received high scores, versus 12 that scored low, Blanton’s group reported in the February 2021 Current Anthropology. The remaining 10 societies partly qualified as good governments. Many practices of societies scoring highest on good government mirrored policies of liberal democracies over the past century, the researchers concluded.

That’s only a partial view of how past governments operated. But surveys of modern nations suggest that no more than half feature strong democratic institutions, Fargher says.

Probing the range of democratic institutions that societies have devised over the millennia may inspire reforms to modern democratic nations facing growing income disparities and public distrust of authorities, Holland-Lulewicz suspects. Leaders and citizens of stressed democracies today might start with a course on power sharing in Indigenous societies. School will be in session at the next meeting of the Muscogee National Council.

Art historian Erin Griffey is a bit of a beauty maven. “I’m one of those people who reads the backs of beauty products,” she says. That’s why, while working on a book about beauty culture in Renaissance Europe, Griffey experienced déjà vu.

She noticed that many ingredients in beauty recipes from the 16th to 18th centuries — compiled from books, cosmetic recipe collections, medical texts, health regimen manuscripts, herbals and pharmacopeias — also appear on modern beauty packaging. For instance, rosewater is used in modern skin-hydrating mists and sulfur is found in some over-the-counter acne creams.
Such similarities are clues to what Renaissance-era people used the products for and how the products worked. But they are not the whole story. That’s because the ancient recipes often also list bizarre or even dangerous ingredients, from bile acids and calves’ hooves to lead and the poisonous bryony plant. To get a better understanding, Griffey wanted to re-create the recipes. So she turned to her colleagues at the University of Auckland in New Zealand. Thus the Beautiful Chemistry Project was born.

The team started with what Griffey calls “sticky recipes” because they’re found in many sources throughout the Renaissance period: rosemary flowers in white wine, myrrh powder with egg white, and the velvety covering of newly grown deer antlers with bean flour.

The recipes tend to be vague and varied. So chemist Michel Nieuwoudt and her team experiment with the measurements and procedures while Griffey searches various sources for more clues to ingredient types and ratios.

“We knew we could not re-create it exactly as is,” Griffey says of the recipe for rosemary flowers in white wine. “We do not have access to the rosemary plants that grew 500 years ago or the wines and whatever their chemical makeup was.” But this legwork “enabled us to get closer to an approximation.”

Nieuwoudt and her team boiled rosemary flowers in round-bottom flasks each filled with a different solution: sweet white wine, dry white wine, ethanol in water or aqua vitae. Once the researchers filtered out the flowers and analyzed the resulting mixtures using gas chromatography and mass spectrometry, they found chemical compounds that are common in today’s skin care products, including soothing camphor, eucalyptol and the fragrant alcohol linalool (SN: 7/22/02).

The Renaissance-era recipe stated the potion would “make the face fair.” Nieuwoudt’s findings suggest how: by toning and moisturizing skin.
The team has also made progress on unlocking the secrets of myrrh powder and egg whites. Experiments suggest that myrrh draws out proteins from egg whites and the egg whites extract resins, sugars and volatiles from the myrrh. That results in a serumlike product that has antiseptic and anti-inflammatory properties and probably stimulates collagen growth, Nieuwoudt says. “It seems there’s a synergy between all of these different ingredients, and this is why it works.”

As for what deer velvet and bean flour may have been used for, the researchers are still teasing out results. And they have yet to tackle recipes with dangerous ingredients.

Eventually, the researchers hope to perfect their re-creations and bring the products to drug store shelves — minus, of course, any unsafe ingredients. “I think people will want to go back to something that is natural, and it’s also appealing for people to think they’re using Renaissance products,” Nieuwoudt says. Until then, the beauty for the researchers lies in “digging [the recipes] out and understanding them.”

If whole organs could be frozen and stored … surgeons would be able to perform far more transplants…. For all their efforts, though, cryobiologists (biologists who study the effects of cold on life) have not been very successful with organ freezing…. Nobody to date has cooled whole mammalian hearts any lower [than −20° Celsius] or longer [than six hours] and revived them.

Update
Scientists still struggle to keep donor hearts on ice for longer than six hours, but it is now possible to store a different organ — the liver — at below-freezing temperatures for more than a day. The challenge has been figuring out how to stop ice from crystallizing and damaging cells. In 2019, scientists reported successfully warming up several human livers after supercooling them for 27 hours (SN: 10/12/19 & 10/26/19, p. 10). This and other preservation methods such as freezing at high pressures or thawing using nanoparticles aren’t yet ready for the operating room, but they have the potential to keep thousands of lifesaving organs from going to waste each year.

For some people, including President Joe Biden and National Institute of Allergy and Infectious Diseases director Anthony Fauci, the relief of vanishing COVID-19 symptoms and a negative test is fleeting. Biden, Fauci and many others have seen their tests turn positive again or have unwelcome symptoms return after taking a five-day course of the antiviral Paxlovid. Other people, including my husband, have had their infections rebound even without taking the drug.

Multiple studies have described cases of “Paxlovid rebound” after treatment. In one, seven Paxlovid-treated patients had the virus rebound to high levels after treatment ended, and symptoms returned for six of them, virologist Jonathan Li and colleagues reported in June in Clinical Infectious Diseases. Samples from three patients even carried infectious virus, a clue that some people who rebound might infect others. Another study that has yet to be peer-reviewed by other researchers found that fewer than 6 percent of people in the study who’d been prescribed Paxlovid had rebound infections in the month after finishing treatment.
It’s unclear why Paxlovid rebound happens, says Li, of Brigham and Women’s Hospital and Harvard Medical School. Studies show that people given the drug still develop a strong immune response to the virus after five days of treatment. “I think what’s happening in that situation is that you’ve got virus replication that’s been inhibited. All of a sudden, the drug has disappeared and the virus has a momentary opportunity to replicate. And it replicates to high levels,” Li says. But by then, the immune system has learned to fend off the coronavirus. If the recently trained immune cells encounter newly made viruses and set off alarm bells, symptoms may briefly come back.

Some people might not want to take the drug because they’re worried about rebound, Li says. But Paxlovid itself probably isn’t the cause. The drug’s not failing. It is still highly effective in preventing severe disease. “I would not hesitate to give my patients Paxlovid,” Li says. “I do tell them to be on the lookout for rebounding symptoms. But it doesn’t dissuade me in terms of prescribing it.”

Fauci took another course of Paxlovid in the wake of his rebound. The U.S. Food and Drug Administration says that there’s no evidence that 10 days of treatment is any more effective than five days, or that patients need a repeat. But, researchers are testing whether taking the drug for a longer period of time might prevent rebound.

Rebounding COVID-19 isn’t limited to patients who take Paxlovid. Li recalls that even in the early days of the pandemic, some patients would come to him in the hospital saying that they’d started to feel better but got worse again. It’s hard to know how to interpret such anecdotal reports, he says. Researchers are still learning what an untreated viral infection can look like in the body. While the virus’s (hopefully) brief invasion may appear straightforward on average — with virus levels in the body increasing to a peak before slowly declining as the person recovers — not everyone follows that pattern.
My husband got COVID-19 two months ago. His symptoms lasted about a week, and he was delighted to see the line on his antigen test getting fainter. Even so, despite feeling perfectly healthy, the line was suddenly back at full strength almost immediately after he added his sample to a new test days later. He was frustrated and, as a social person, lamented having to stay isolated.

Studies show he’s not alone. When Li and colleagues studied the course of disease in COVID-19 clinical trial participants who received a placebo treatment, 1 in 8 people experienced a rebound, with symptoms coming back for 1 in 4 people. That rebound, however, typically lasted about a day, and few had both high viral loads and returning symptoms, the team reports in a preliminary study posted August 2 at medRxiv.org that hasn’t yet been peer-reviewed by other scientists.

In this case, there’s no disappearing drug. Any returning symptoms without a positive test might be from something else such as allergies or a different respiratory virus, Li says. It’s also possible that the virus is replicating in different parts of the body at different times. Some tests might end up negative when the body eliminates virus from the throat, for example, but it’s still replicating at low levels in the nose.

That latter scenario may have happened with my husband. In a confusing twist, he tested negative on two saliva PCR tests while continuing to test positive on nasal antigen tests. A PCR test is far more sensitive, so we expected the opposite to happen. Since experts say to consider a positive antigen test as a sign you’re still contagious, he stayed isolated until he finally tested negative on an antigen test two weeks after his first symptoms appeared.

Luckily, he’s fully recovered now, and not at all eager for a repeat experience. That means we’re both still masking in public spaces and taking other precautions. We know we’re not done with this pandemic.

Potential hints of weird new particles in a dark matter detector have evaporated with new data.

Following up on a beguiling result from its predecessor experiment, the XENONnT experiment found no sign of extra blips that could point to new particles or another phenomenon, scientists report July 22 in Vienna at the International Conference on Identification of Dark Matter.

The XENONnT experiment (pronounced “xenon n ton”), at the Gran Sasso National Laboratory in Italy, uses 5.9 metric tons of liquid xenon to search for dark matter, an elusive substance that so far has been seen only via its gravitational effects in the cosmos (SN: 10/25/16). The detector is designed to look for dark matter particles crashing into xenon atoms’ nuclei, causing them to recoil. But the detector can also spot recoiling electrons.
In 2020, a smaller version of the experiment, called XENON1T, reported greater-than-expected numbers of those ricocheting electrons (SN: 6/17/20). “This caused a lot of stir when we published it,” says physicist Rafael Lang of Purdue University in West Lafayette, Ind.

That surplus, some scientists suggested, could have been explained by some unexpected new physics, such as hypothetical lightweight particles that may originate from the sun called solar axions. But the excess wasn’t large enough to be convincing, so more data were needed.

In the new analysis, which uses about 97 days of data, XENONnT spotted as many electron recoils as expected due to known particle interactions, the researchers also reported in a paper posted on the experiment’s website. Scientists don’t know what caused the extra detections in the previous experiment, but it’s possible it was merely a statistical fluke, Lang says. Or it may have been due to small amounts of tritium — hydrogen atoms with two neutrons in their nuclei — in the detector.

With the red herring out of the way, XENONnT researchers are now combing through their data for nuclear recoils, in hopes of detecting the real deal.

It may soon be too late to end the global monkeypox epidemic.

“We are losing the window to be able to contain this outbreak,” Boghuma Titanji, an infectious diseases doctor and virologist at Emory University in Atlanta said July 21 during a seminar sponsored by the Harvard Kennedy School’s Belfer Center for Science and International Affairs.

On July 23, Tedros Adhanom Ghebreyesus, director of the World Health Organization declared the global outbreak of monkeypox is a public health emergency of international concern, the organization’s highest state of alert. The WHO committee evaluating the matter was split on whether the outbreak constitutes an international emergency, but Ghebreyesus decided that enough conditions were met to warrant the designation.
Monkeypox has infected more than 15,700 people since the beginning of May, according to Global.health (SN: 5/26/22). More than 2,800 cases have been reported in the United States as of July 22, the U.S. Centers for Disease Control and Prevention report.

“Although I am declaring a public health emergency of international concern, for the moment this is an outbreak that is concentrated among men who have sex with men, especially those with multiple sexual partners,” Ghebreyesus said in a statement. “That means that this is an outbreak that can be stopped with the right strategies in the right groups.”

Monkeypox has caused outbreaks for decades in some parts of Africa, Anne Rimoin, an epidemiologist at the UCLA Fielding School of Public Health, said at the Harvard seminar. But the virus “has been neglected by the global health community.” Monkeypox “has been giving us warning signals” for years in Congo, Nigeria and other parts of West Africa, but has only gotten attention once it recently started causing cases outside of the continent, Rimoin said.

There has been no concerted global effort to contain the virus, which is related to smallpox, Titanji said. Each country has been left to set its own policies.

That has led to disparities. Well-resourced countries have had at least some access to testing, vaccines and medications, which may help limit the spread of the virus or the severity of the disease. Resource-poor nations often lack that access, leaving them with limited ability to track or control the virus. Continued spread of monkeypox in resource-poor countries could leave places that do manage to contain an initial outbreak vulnerable to reintroductions, Jay K. Varma, director of the Cornell Center for Pandemic Prevention and Response in New York City, said in the seminar. The WHO emergency declaration may lead to a more concerted international effort that could make more resources available to contain the spread of the virus.

Even for the wealthiest countries, containing the outbreak is a challenge. Questions abound about how the virus is transmitted, and whether vaccines and treatments — when people can get them — can halt its spread. Even diagnosing the disease can be tricky, with testing often hard to come by and missed diagnoses potentially leading to more cases.

The vast majority of monkeypox cases in the global outbreak have been among men who have sex with men. Of 528 people infected with monkeypox in 16 countries, 98 percent identified as gay or bisexual men, researchers report July 21 in the New England Journal of Medicine.

In some countries with outbreaks, “gay men are criminalized,” Kai Kupferschmidt, a correspondent for Science magazine, said during the seminar. In those countries, “people cannot access good information to help them keep from getting infected and cannot access health care if they do get infected. In these countries, it becomes really difficult to even see the problem,” he said.

Ghebreyesus urged all countries to “work closely with communities of men who have sex with men, to design and deliver effective information and services, and to adopt measures that protect the health, human rights and dignity of affected communities. Stigma and discrimination can be as dangerous as any virus,” he said in a statement.

Doctors might also miss cases of monkeypox because of the unusual presentation of the illness in this outbreak, compared with earlier outbreaks. For instance, in the NEJM study, only a quarter of patients had monkeypox lesions on their faces and only 10 percent had the sores on their palms or soles of their feet. Those body parts have been among some of the most affected in other outbreaks.

Instead, 73 percent of people in the study had lesions in the anal and genital regions and 55 percent on the trunk, arms or legs. Some people also had lesions in their mouths and throats. Most of the people in the study had fewer than 10 lesions, with 54 people having only a single lesion on their genitals, making confusion with herpes or syphilis possible, even easy.

Seventy people in the study were admitted to the hospital. Of those, 21 were hospitalized because of pain, mostly severe rectal pain. Others had eye lesions, kidney damage, inflammation of the heart or throat swelling that prevented them from taking in liquids.

Those complications fit with what health officials across the United States have been seeing. “While mortality appears very low, which is great, morbidity has been much higher than any of us expected,” Mary Foote, the medical director of the New York City Department of Health and Mental Hygiene, said July 14 in a news briefing sponsored by the Infectious Diseases Society of America.

“A lot of people with this infection are really suffering, and some may be at risk of permanent damage and scarring. We see many people with symptoms so severe that they are unable to go to the bathroom, urinate or eat without excruciating pain,” Foote said.

A small number of women and children have also gotten monkeypox in the outbreak. Two children in the United States have been diagnosed with monkeypox, CDC director Rochelle Walensky said July 22 in an interview with the Washington Post. Both children were social contacts of men that have sex with men, she said.

A child in the Netherlands who had no contact with anyone known to be infected with the virus also got monkeypox, researchers report July 21 in Eurosurveillance. His case raises the possibility that monkeypox may be spreading undetected more broadly in communities than realized.

“I don’t think it’s surprising that we are occasionally going to see cases in individuals who are not gay, bisexual or other men who have sex with men. The social networks we have as humans mean we have contact with a lot of different people,” Jennifer McQuiston, deputy director of the CDC’s Division of High Consequence Pathogens and Pathology said July 22 during a White House news briefing.

Exactly how the child in the Netherlands became infected is a matter of speculation. Monkeypox typically spreads among people through close contact with infected people or with clothing, bedding or towels used by people with the disease. Examination of viral DNA showed that the boy isn’t connected to any of the known cases in the Netherlands. He traveled to Turkey in June and may have gotten infected there or while traveling.

The boy has very low levels of IgA antibodies, which patrol mucous membranes and help prevent infections there. Low levels of the antibodies could make him vulnerable to respiratory infections. People can get infected with monkeypox through droplets given off by infected people during close face-to-face interactions, such as close conversation, kissing or during medical exams. But patterns of infection clearly indicate that monkeypox isn’t airborne the way COVID-19 or other respiratory viruses are, Kupferschmidt said.

Details of how monkeypox spreads are still unknown. For instance, researchers don’t know whether the virus can be transmitted through semen as a sexually transmitted disease. Researchers have found evidence of viral DNA in semen, saliva, urine and feces, but that may just be inactive remnants of the virus. So far, no researchers have reported finding infectious virus in genital body fluids that might be exchanged during sex. Also unknown is whether getting infected through mucous membranes during sexual contact would shield against catching the virus later, Rimoin said.

Scientists are questioning whether the monkeypox virus has changed or whether it has simply found a niche social-sexual network among gay and bisexual men that may enable the virus to spread more efficiently, Titanji said. It may be that there are different transmission patterns in historically affected countries and newly affected countries that require different strategies to stop the spread, she said.

Researchers also need to do good studies to figure out how well vaccines and therapeutics work and under what circumstances, Rimoin said. WHO’s emergency declaration includes recommendations for increasing testing and surveillance and for seeding up research on vaccines, treatments and other virus containment measures.

One thing is clear, Rimoin said. “We’re giving this virus room to run like it never has before.” People have passed the buck, leaving others to work out the problem of monkeypox, she said. But now, “it’s everybody’s problem to solve.”

How descendants of cannibals evolved abilities to share a home mostly without killing each other — never mind the rare oopsie snack — resonates after several pandemic years.

Among the many kinds of velvety Delena huntsman spiders, four species from Australia show what for their kind is a downright freaky tolerance between a mom and her live-in offspring. “Cannibalism might happen occasionally, but with Delena cancerides, it’s almost never,” says behavioral ecologist Linda Rayor of Cornell University, who has studied them in the wild and in her lab for 20 years.
Not eating their own kind isn’t really the oddity here: Cannibalism varies a lot among spider species, Rayor says, but overall, it’s mostly a move of solitary kinds of spiders if they meet outside of flirting or baby-guarding demands (SN: 4/25/22).

A small number of Delena species, however, generally tolerate their own kind. The only exception Rayor sees in D. cancerides are a wild-caught female’s takedown of a full-grown male still in her cage after she lays eggs. “Wild-caught females are very intolerant of males who stick around too long,” she says.

What’s really strange, at least in the arachnid world, is these spiders’ shared family life. Out of the more than 50,000-plus known spider species, biologists classify fewer than 80 as truly social. In the most complex, hundreds or even thousands of females spin a great airy silken city, where some stay their entire lives. However, Rayor says, “my huntsman don’t do that.”

Some other biologists wouldn’t consider the Delena spiders Rayor studies as fully social — no spun-silk Sydney. Yet these spiders are not truly solitary either. A female doesn’t spin a web but shelters in a crevice, perhaps behind peeling bark on an acacia tree or under a slab of rock. These crevice-dwellers’ bodies look unusually flattened in profile: “a credit-card spider,” one scientist called the species, with some poetic license.

When a female triumphs in finding real estate, the kids can linger for months in her splendid mom cave — the kids with no sex life yet, that is. Never mind that older offspring already go out hunting on their own at night, or that often one or two later clutches of little ones hatch before the older ones leave. Spider moms guarding poppyseed-tiny hatchlings are common. Living with capable, nearly grown offspring, is strange in the arachnid world.
The most sociable of these sort-of tolerant moms, D. cancerides, lets a cohort of youngsters hang around the home for about a year after hatching. That’s a good portion of life for spiders that live only two and a half years. One of the reasons for doing so may sound familiar: Suitable housing can be hard to find.

Rayor once thought hanging with mom was an Australian thing, but she has now learned about tolerant moms from Madagascar in a Damastes species. To study the evolution of traits that add up to family life in the five species, Jacob Gorneau, now at the California Academy of Sciences in San Francisco, and his Cornell colleagues used four genes from spiders in 37 huntsman genera to create the most ambitious genealogical tree yet of the family. Then Rayor turned to her decades of data to see what behaviors appeared on branches leading to lingering kids.

For instance, a form of egg sac called “plastered” — not drunk but spun like a firmly anchored splat on a surface of spider retreats — shows up in branches with the family-tolerant behavior, the researchers report in the September issue of Molecular Phylogenetics and Evolution.

Spiders spin various shapes of outer sacs that discourage egg raiders. Spiders in a fixed retreat can conveniently anchor a sac, unlike some other moms that carry eggs with them. Also the more spread-out, plastered form might — Rayor emphasizes this is speculation — fit better in tight crevices than the puffier throw-pillow styles of egg sacs would.

Delena spiderlings still carry abundant egg yolk with them when they clamber out of the egg sac. They don’t eat until after their first molt. “They’ve got these big, fat, green abdomens,” Rayor says. “They don’t have long legs, so they waddle.”

Once they molt, one benefit of this family lifestyle could be table scraps for the littles. Very young spiderlings are “ridiculously small,” Rayor says, and can handle food only about the size of a fruit fly. The chance to sneak extra shreds of meat from an older sib could greatly boost nutrition. Older sibs probably would rather not share, but Rayor sees “tolerated theft.”

Cute babies may not matter to a spider mom, but maybe they should to humans. Gorneau, once “very afraid of spiders,” wants to fight the stereotype of spiders as aggressive dangers. Rayor’s spiders strike him as “stoic,” mostly sitting quietly. Rayor’s lab full of spiders in their homes, he now finds, is a “calming environment.”

Dinosaurs might have been endothermic, or warm-blooded…. The combination of large size, endothermy and naked skin may explain the extinction of dinosaurs. About 65 million years ago there was a sharp drop in temperature…. Dinosaurs, lacking skin insulation and too large to burrow underground … could not survive. Meanwhile, evidence has come that … the shells [of their eggs] became progressively thinner … too fragile to support the growing embryo.

Update
Some dinosaurs may have been warm-blooded and some could have laid soft-shelled eggs (SN: 7/12/14, p. 6). But neither trait led to the reptiles’ demise. In the late 1970s, geologists proposed that an asteroid strike triggered a mass extinction (1/25/92, p. 56), killing more than 75 percent of life on Earth. That theory is now widely accepted. Scientists have even found the killer’s calling card: a crater about 180 kilometers wide on the coast of the Yucatán Peninsula in Mexico. The asteroid probably crash landed there in the springtime 66 million years ago, fossils hint (SN: 3/26/22, p. 8).

A century from now, when biologists are playing games of clones and engineers are playing games of drones, physicists will still pledge their loyalty to the Kingdoms of Substance and Force.

Physicists know the subjects of these kingdoms as fermions and bosons. Fermions are the fundamental particles of matter; bosons transmit forces that govern the behavior of the matter particles. The math describing these particles and their relationships forms the “standard model” of particle physics. Or as Nobel laureate Frank Wilczek calls it, “The Core Theory.”
Wilczek’s core theory differs from the usual notion of standard model. His core includes gravity, as described by Einstein’s general theory of relativity. General relativity is an exquisite theory of gravity, but it doesn’t fit in with the math for the standard model’s three forces (the strong and weak nuclear forces and electromagnetism). But maybe someday it will. Perhaps even by 100 years from now.

At least, that’s among the many predictions that Wilczek has made for the century ahead. In a recent paper titled “Physics in 100 Years,” he offers a forecast for future discoveries and inventions that science writers of the future will be salivating over. (The paper is based on a talk celebrating the 250th anniversary of Brown University. He was asked to make predictions for 250 years from now, but regarded 100 as more reasonable.)

Wilczek does not claim that his forecast will be accurate. He considers it more an exercise in imagination, anchored in thorough knowledge of today’s major questions and the latest advances in scientific techniques and capabilities. Where those two factors meet, Wilczek sees the potential for premonition. His ruminations result in a vision of the future suitable for a trilogy or two of science fiction films. They would involve the unification of the kingdoms of physics and a more intimate relationship between them and the human mind.

Among Wilczek’s prognostications is the discovery of supersymmetric particles, heavyweight partners to the matter and force particles of the Core Theory. Such partner particles would reveal a deep symmetry underlying matter and force, thereby combining the kingdoms and further promoting the idea of unification as a key path to truth about nature. Wilczek also foresees the discovery of proton decay, even though exhaustive searches for it have so far failed to find it. If protons disintegrate (after, on average, trillions upon trillions of years), matter as we know it has a limited lease on life. On the other hand, lack of finding proton decay has been a barrier to figuring out a theory that successfully unifies the math for all of nature’s particles and forces. And Wilczek predicts that:

The unification of gravity with the other forces will become more intimate, and have observable consequences.

He also anticipates that gravity waves will be observed and used to probe the physics of the distant (and early) universe; that the laws of physics, rather than emphasizing energy, will someday be rewritten in terms of “information and its transformations”; and that “biological memory, cognitive processing, motivation, and emotion will be understood at the molecular level.”

And all that’s just the beginning. He then assesses the implications of future advances in computing. Part of the coming computation revolution, he foresees, will focus on its use for doing science:

Calculation will increasingly replace experimentation in design of useful materials, catalysts, and drugs, leading to much greater efficiency and new opportunities for creativity.

Advanced calculational power will also be applied to understanding the atomic nucleus more precisely, conferring the ability…

to manipulate atomic nuclei dexterously … enabling (for example) ultradense energy storage and ultrahigh energy lasers.

Even more dramatically, computing power will be employed to enhance itself:

Capable three-dimensional, fault-tolerant, self-repairing computers will be developed.… Self-assembling, self-reproducing, and autonomously creative machines will be developed.

And those achievements will imply that:

Bootstrap engineering projects wherein machines, starting from crude raw materials, and with minimal human supervision, build other sophisticated machines (notably including titanic computers) will be underway.

Ultimately, such sophisticated computing machines will enable artificial intelligence that would even impress Harold Finch on Person of Interest (which is probably Edward Snowden’s favorite TV show).

Imagine, for instance, the ways that superpowerful computing could enhance the human senses. Aided by electronic prosthetics, people could experience the full continuous range of colors in the visible part of the electromagnetic spectrum, not just those accessible to the tricolor-sensitive human eye. Perhaps the beauty that physicists and mathematicians “see” in their equations can be transformed into works of art beamed directly into the brain.

Artificial intelligence endowed with such power would enable many other futuristic fantasies. As Wilczek notes, the “life of mind” could be altered in strange new ways. For one thing, computationally precise knowledge of a state of mind would permit new possibilities for manipulating it. “An entity capable of accurately recording its state could purposefully enter loops, to re-live especially enjoyable episodes,” Wilczek points out.

And if all that doesn’t sound weird enough, we haven’t even invoked quantum mechanics yet. Wilczek forecasts that large-scale quantum computers will be realized, in turn leading to “quantum artificial intelligence.”

“A quantum mind could experience a superposition of ‘mutually contradictory’ states, or allow different parts of its wave function to explore vastly different scenarios in parallel,” Wilczek points out. “Being based on reversible computation, such a mind could revisit the past at will, and could be equipped to superpose past and present.”

And with quantum artificial intelligence at its disposal, the human mind’s sensory tentacles will not merely be enhanced but also dispersed. With quantum communication, humans can be linked by quantum messaging to sensory devices at vast distances from their bodies. “An immersive experience of ‘being there’ will not necessarily involve being there, physically,” Wilczek writes. “This will be an important element of the expansion of human culture beyond Earth.”

In other words, it will be a web of intelligence, rather than a network of physical settlements, that will expand human culture throughout the cosmos. Such “expanded identities” will be able to comprehend the kingdoms of substance and force on their own quantum terms, as the mind itself merges with space and time.

Wilczek’s visions imply a future existence in which nature is viewed from a vastly different perspective, conditioned by a radical reorientation of the human mind to its world. And perhaps messing with the mind so drastically should be worrisome. But let’s not forget that the century gone by has also messed with the mind and its perspectives in profound ways — with television, for instance, talk radio, the Internet, smartphones and blogs. A little quantum computer mind manipulation is unlikely to make things any worse.

With delicate hues of purple and pink, a lab technique called gram staining has reliably characterized bacteria for more than a century. Yet many scientists are mistaken about why the vivid method works, new research finds.

Contrary to standard scientific texts, the purple dye called crystal violet, a main ingredient in gram staining, does not actually enter bacterial cells, researchers report April 27 in ACS Chemical Biology. Instead, the dye gets trapped in a tight package of sugar-filled polymers, called peptidoglycan, which envelops bacterial cells. The thickness and integrity of the sweet bacterial armor determines whether crystal violet leaves a cell purple or not. That royal shade, or lack of it, reveals a cell’s type of outer structure.
Published by Hans Christian Gram in 1884, gram staining distinguishes gram-positive bacteria (purple) from gram-negative bacteria (pink). Gram-positive critters, such as staph, have a thick peptidoglycan layer that shields an inner cellular membrane. Gram-negative cells, such as E. coli, have a thin peptidoglycan layer sandwiched between a porous outer membrane and an inner membrane.
Microbiologists thought that crystal violet could easily pass through membranes and into both cell types, says microbiologist Moselio Schaechter, an emeritus professor at Tufts University School of Medicine in Boston. A subsequent harsh shower of alcohol could then corrode both cell types’ membranes. This particularly clobbers gram-negative cells’ outer structures, including the thin layer of peptidoglycan which is bound to the outer membrane, allowing the purple dye to flush away. Meanwhile, gram-positive cells’ sturdier layer of peptidoglycan warps a bit but stays largely intact, keeping the microbes purple. The colorless gram-negative cells can then be stained with another dye, such as safranine, tinting the cells pink.

But that explanation is incorrect, says physical chemist Michael Wilhelm of Temple University in Philadelphia. Using a recently developed spectroscopy technique that monitors molecules as they traverse membranes, Wilhelm and colleagues found that crystal violet doesn’t cross the inner membrane of either cell type.

Instead, crystal violet seeps into the cracks of peptidoglycan, which acts like a “brick wall of sugar,” Wilhelm says. A gram-negative cell’s thin wall crumbles in the alcohol wash and releases the dye, he explains. In gram-positive cells, crystal violet slowly drains from the thick peptidoglycan barrier, but not quickly enough to leave the cell colorless during the protocol.

The study is fascinating, says microbiologist Rita Moyes of Texas A&M University in College Station. Scientists should continue to use new technologies to study old techniques, she says.

“Who’d have thought gram stain lecture material needed an update?” says microbiologist Mark Forsyth of the College of William & Mary in Williamsburg, Va. But, he says, “it may take a while to convince old professors like me to actually change their shtick about how this historic stain works.”