Drugs for reflux disease in infants may come with unintended consequences

When my girls were newborns, I spent a lot of time damp. Fluids were everywhere, some worse than others. One of the main contributors was milk, which, in various stages of digestion, came back to haunt me in a sloppy trail down my back.

I was sometimes alarmed at the volume of fluid that came flying out of my tiny babies. And I remember asking our pediatrician if it was a problem. We were lucky in that the amount and frequency of the regurgitations didn’t seem to signal trouble.

But some babies spit up a lot more, and seem to be in distress while doing so. That’s led doctors to prescribe antacids to treat reflux disease in these infants. A U.S.-based survey found that from 2000 to 2003, infant use of a type of antacid called proton-pump inhibitors quadrupled.

Those numbers point to worried doctors and parents who want to help babies feel better. The problem, though, is that antacids come with side effects. Mucking with acid levels can affect the body beyond the stomach, and these unintended effects may be even more meddlesome in babies.

“What we found in adults and what we’re starting to see more in children is that [the drugs] are not as benign as we used to think,” says U.S. Air Force Captain Laura Malchodi, a pediatrician at Walter Reed National Military Medical Center in Bethesda, Md.

Infants who took proton-pump inhibitors, a class of drugs that includes Prilosec and Nexium, in their first six months of life broke more bones over the next several years than children who didn’t receive the drugs. That example comes from research Malchodi presented May 7 at the 2017 Pediatric Academic Societies Meeting in San Francisco.

Malchodi and her colleagues examined medical records of nearly 900,000 healthy children. Of those, about 7,000 were prescribed proton-pump inhibitors by the time they were 6 months old. About 67,000 were prescribed histamine H2-blocking drugs, such as Zantac or Pepcid, and about 11,000 babies were prescribed both types of drugs.
Children who had received proton-pump inhibitors, either alone or in combination with a histamine H2-blocker, had more fractures over the next five years than children who weren’t prescribed that type of drug. The researchers tried to rule out other differences between the groups of babies that might explain the higher number of fractures. When those differences were removed from the analysis, proton-pump inhibitor prescriptions were still linked to fractures.

The study can’t say whether proton-pump inhibitors definitely caused weaker bones. But that’s not an unreasonable hypothesis given what’s seen in adults, for whom the link between long-term use of proton-pump inhibitors and broken bones is stronger.

If proton-pump inhibitors do interfere with bones, it’s still a mystery exactly how. One idea was that the drugs hinder calcium absorption, leading to weaker bones. That idea has fallen out of favor, Malchodi says. Another proposal centers on cells called osteoclasts. To do their job, these cells rely on proton pumps to create acidic pockets around bones. But if osteoclasts aren’t working properly, “in the end, what you get is disorganized bone,” Malchodi says.

Reflux disease is not the same thing as reflux, which babies are nearly guaranteed to experience. For one thing, the amount of liquid they’re slurping down relative to their body weight is huge. And that liquid is held down by an esophageal sphincter that’s often underdeveloped in babies. (One technical term for reflux is “poor gastric compliance,” but I bet you’ve got more colorful descriptions.)

Antacids won’t stop babies from spitting up, says Malchodi. “We definitely counsel parents all the time that this is not going to stop the reflux,” she says. Instead, the drugs are thought to change the pH of the liquid coming back up in an attempt to make it less irritating.

Some babies may need that pharmaceutical help. But many may not. If babies are growing well and don’t seem to be in long-lasting distress, then it’s possible that they may need the “tincture of time” to outgrow the reflux. (Malchodi points out that so-called “happy spitters” are probably not smiling while they’re barfing, because obviously, throwing up is not fun. It’s just that these babies don’t seem to be bothered long after the spitting.)

She hopes that her research and other studies like it will prompt more careful discussions between parents and doctors before antacids are prescribed. And if they are deemed necessary, “have a stop point in mind,” she says.

Why you can hear and see meteors at the same time

For centuries, skywatchers have reported seeing and simultaneously hearing meteors whizzing overhead, which doesn’t make sense given that light travels roughly 800,000 times as fast as sound. Now scientists say they have a potential explanation for the paradox.

The sound waves aren’t coming from the meteor itself, atmospheric scientists Michael Kelley of Cornell University and Colin Price of Tel Aviv University propose April 16 in Geophysical Research Letters. As the leading edge of the falling space rock vaporizes, it becomes electrically charged. The charged head produces an electric field, which yields an electric current that blasts radio waves toward the ground. As a type of electromagnetic radiation, radio waves travel at the speed of light and can interact with metal objects near the ground, generating a whistling sound that people can hear.

Just 0.1 percent of the radio wave energy needs to be converted into sound for the noise to be audible as the meteor zips by, the researchers estimate. This same process could explain mysterious noises heard during the aurora borealis, or northern lights (SN: 8/9/14, p. 32). Like meteors, auroras have been known to emit radio wave bursts.

Scalding hot gas giant breaks heat records

The planet KELT 9b is so hot — hotter than many stars — that it shatters gas giant temperature records, researchers report online June 5 in Nature.

This Jupiter-like exoplanet revolves around a star just 650 light-years away, locked in an orbit that keeps one side always facing its star. With blistering temps hovering at about 4,300o Celsius, the atmosphere on KELT 9b’s dayside is over 700 degrees hotter than the previous record-holder — and hot enough that atoms cannot bind together to form molecules.
“It’s like a star-planet hybrid,” says Drake Deming, a planetary scientist at the University of Maryland in College Park who was not involved in the research. “A kind of object we’ve never seen before.”

KELT 9b also boasts an unusual orbit, travelling around the poles of its star, rather than the equator, once every 36 hours. And radiation from KELT 9b’s host star is so intense that it blows the planet’s atmosphere out like a comet tail — and may eventually strip it away completely.

The planet is so bizarre that it took scientists nearly three years to convince themselves it was real, says Scott Gaudi of Ohio State University. Deming suspects KELT 9b is “the tip of the iceberg” for an undiscovered population of scalding-hot gas giants.

Jupiter’s precocious birth happened in the solar system’s first million years

Jupiter was an early bloomer. New measurements of meteorite ages suggest that the giant planet’s core must have formed within the solar system’s first million years. If so, Jupiter’s presence could help explain why the inner planets are so small — and possibly even be responsible for Earth’s existence.

Previously, astronomers’ best constraints on Jupiter’s age came from simulations of how solar systems form in general. Gas giants like Jupiter grow by accreting gas from spinning disks of gas and dust around a young star. Those disks typically don’t last more than 10 million years, so astronomers inferred that Jupiter formed by the time that disk dissipated.
“Now we can use actual data from the solar system to show Jupiter formed even earlier,” says Thomas Kruijer, who did the research while at the University of Münster in Germany. Kruijer, now at Lawrence Livermore National Laboratory in California, and his team report Jupiter’s new age in the Proceedings of the National Academy of Sciences the week of June 12.

To study one of the biggest objects in the solar system, Kruijer and colleagues turned to some of the smallest: meteorites. Most meteorites come from the asteroid belt currently located between Mars and Jupiter but probably were born elsewhere.

Luckily, meteorites carry a signature of their birthplaces. The gas and dust disk that the planets formed from had different neighborhoods. Each had its own “zip code,” areas enriched in certain isotopes, or different masses of the same elements. Careful measurements of a meteorite’s isotopes can point to its home.

Kruijer and colleagues selected 19 samples of rare iron meteorites from the Natural History Museum in London and the Field Museum in Chicago. These rocks represent the metal cores of the first asteroid-like bodies to congeal as the solar system was forming.

The team dissolved about a gram of each sample in a solution of nitric acid and hydrochloric acid. “It smells terrible,” Kruijer says.
Then the researchers separated out the elements tungsten — a good tracer of both a meteorite’s age and birthplace — and molybdenum, another tracer of a meteorite’s home.

By measuring the relative amounts of molybdenum-94, molybdenum-95, tungsten-182 and tungsten-183, Kruijer and his team identified two distinct groups of meteorites. One group formed closer to the sun than Jupiter is today; the other formed farther from the sun.

The tungsten isotopes also showed that both groups existed at the same time, between about 1 million and 4 million years after the start of the solar system about 4.57 billion years ago (SN Online: 8/23/10). That means something must have kept them separated.

The most likely candidate is Jupiter, Kruijer says. His team’s calculations suggest that Jupiter’s core had probably grown to about 20 times the mass of the Earth in the solar system’s first million years, making it the oldest planet. Its presence would have created a gravitational barrier that kept the two meteorite neighborhoods segregated. Jupiter would then have continued growing at a slower rate for the next few billion years.

“I have high confidence that their data is excellent,” says cosmochemist Meenakshi Wadhwa of Arizona State University in Tempe. The suggestion that Jupiter held the different meteorites apart is “a little more speculative, but I buy it,” she adds.

Jupiter’s early entrance could also explain why the inner solar system lacks any planets larger than Earth. Many extrasolar planetary systems have large close-in planets, from rocky super-Earths (about two to 10 times the mass of Earth) to gassy mini-Neptunes or hot Jupiters. Astronomers have puzzled over why our solar system looks so different.

An early Jupiter’s gravity could have kept most of the planet-forming disk away from the sun, meaning there was less raw material for the inner planets. This picture is consistent with other work suggesting a young Jupiter wandered through the inner solar system and swept it clean (SN: 4/2/16, p.7), Kruijer says.

“Without Jupiter, we could have had Neptune where Earth is,” Kruijer says. “And if that’s the case, there would probably be no Earth.”

African farmers’ kids conquer the marshmallow test

Children of Nso farmers in Cameroon know how to master the marshmallow test, which has tempted away the self-control of Western kids for decades.

In a direct comparison on this delayed gratification task, Cameroonian youngsters leave middle-class German children in the dust when challenged to resist a reachable treat while waiting for another goodie, a new study finds.

Of 76 Nso 4-year-olds, 53, or nearly 70 percent, waited 10 minutes for a second treat — a small local pastry called a puff-puff — without eating the puff-puff placed on a table in front of them, say psychologist Bettina Lamm of Osnabrück University in Germany and colleagues.
Only 35 of 125 German 4-year-olds, or 28 percent, successfully waited for their choice of a second lollipop or chocolate bar.

The study, which is the first to administer the marshmallow test to non-Western kids, shows that cultural styles of child raising can dramatically shift how self-control develops, Lamm’s team contends online June 6 in Child Development.

“The disparity between German and Nso cultures on the marshmallow test is huge,” says psychologist Ozlem Ayduk of the University of California, Berkeley. She concurs that parenting practices among Nso farmers may at least partly boost children’s ability to delay gratification.

Marshmallow tests conducted over the past 50 years have found that, as in the new study, a minority of children in Western countries manage to wait for a second treat without munching the first one (SN: 11/15/14, p. 28). And kids best able to wait out the test display academic and social advantages decades later (SN: 10/8/11, p. 12).

A Western cultural emphasis on raising children to be independent and to express what they want and how they feel presents challenges to self-control, Lamm says. Delaying a reward, as in the marshmallow test, stirs a frustrating feeling of powerlessness, her team proposes.
The kids in the new study were part of a long-term study of cultural differences in memory and learning. Age-appropriate assessments occurred three times during the kids’ first year of life and at ages 3 and 4. Only 4-year-olds took the marshmallow test. Among 63 of the German youngsters videotaped in play sessions with their mothers at age 9 months, those whose mothers were most lenient in letting them determine what to do displayed the least patience on the marshmallow test at age 4, the researchers say.

Researchers have long argued that “authoritative parenting,” marked by giving children freedom within specific limits, fosters self-control needed for academic and social success (SN: 8/19/89, p. 117). German kids who waited for a second treat had mothers who dealt with them authoritatively as 9-month-olds, Lamm says.

Nso mothers typically had an authoritative parenting style, keeping their kids close and training them to keep emotions in check and respect their elders, especially those high in a community’s pecking order. For 57 Nso kids recorded in play with their mothers at age 9 months, mothers consistently took the lead in organizing play activities.

Nso children’s self-control grew out of their mothers’ authoritarian, controlling parenting style, Lamm suspects.

Children also displayed cultural differences in how they tried to resist temptation during the marshmallow test. German kids tried to distract themselves while waiting for a second treat by moving about, turning around, singing, talking and even leaving the room. Nso youngsters waiting for a second treat exhibited little emotion and remained largely still. Eight of them fell asleep in their chairs.

Some previously tested Western children have rested their heads on the table and taken naps as a tactic to ignore available treats. But Nso kids appeared to zonk out spontaneously, slumping over in their chairs, Lamm says.

As a result of authoritarian parenting practices, Nso kids either squelch negative emotions or experience negative emotions in a different, more controllable way than Western peers do, she proposes.

Ayduk notes that it’s not clear whether Nso youngsters truly had greater self-control or if, true to farming community standards, they simply obeyed adults who asked them to wait for a second puff-puff, Ayduk adds.

While Nso values and parenting techniques generally characterize small-scale farming populations, especially in Africa, hunter-gatherers are another story, says anthropologist Barry Hewlett of Washington State University in Vancouver. Traditional hunter-gatherer groups value individual freedom and consider everyone to be relatively equal, regardless of age. Parents usually don’t tell their kids what to do, and children show little deference to parents and elders.

No hunter-gatherer kids have taken the marshmallow test. Hewlett expects most would scarf an available treat right away.

Gecko-inspired robot grippers could grab hold of space junk

Get a grip. A new robotic gripping tool based on gecko feet can grab hold of floating objects in microgravity. The grippers could one day help robots move dangerous space junk to safer orbits or climb around the outside of space stations.

Most strategies for sticking don’t work in space. Chemical adhesives can’t withstand the wide range of temperatures, and suction doesn’t work in a vacuum.

Adhesives inspired by gecko feet — which use van der Waals forces to cling without feeling sticky (SN Online: 11/18/14) — could fit the bill, says Mark Cutkosky of Stanford University, whose team has been designing such stickers for more than a decade. Now his team has built robotic gripper “hands” that can grapple objects many times their size without pushing them away, the researchers report June 28 in Science Robotics.
The team first tested the grippers in the Robo-Dome, a giant air hockey table at NASA’s Jet Propulsion Laboratory in Pasadena, Calif., where two 370-kilogram robots gently pushed each other around using a small square of gecko gripper.

Then last summer, Aaron Parness and Christine Fuller, of the Jet Propulsion Lab, and Hao Jiang of Stanford took the full gripper hand, which includes several patches of gripping material in a specific arrangement, on a microgravity flight in NASA’s Weightless Wonder aircraft. The team used the hand to grab and release a cube, cylinder and beach ball, which represented satellites, spent rockets or fuel tanks, and pressure vessels.

Gripper hands could be used to repair or move dead satellites, or help miniature satellites called CubeSats stick to larger spacecraft like barnacles, Parness says.

China’s quantum satellite adds two new tricks to its repertoire

A record-breaking quantum satellite has again blown away the competition, achieving two new milestones in long-distance quantum communications through space.

In June, Chinese researchers demonstrated that the satellite Micius could send entangled quantum particles to far-flung locations on Earth, their properties remaining intertwined despite being separated by more than 1,200 kilometers (SN Online: 6/15/17). Now researchers have used the satellite to teleport particles’ properties and transmit quantum encryption keys. The result, reported in two papers published online July 3 and July 4 at arXiv.org, marks the first time the two techniques have been demonstrated in space.
In quantum teleportation, the properties of one particle are transferred to another. The scientists first sent particles of light, or photons, from the ground to the satellite — a distance of up to 1,400 kilometers. When the researchers made particular measurements of other photons on the ground, the spacefaring particles took on the properties of the landlubbers, thanks to quantum entanglement between the earthbound and satellite-based particles. Although it’s a far cry from the Star Trek variety of teleportation, the process is an important ingredient of quantum communication.

Quantum key distribution is a method of creating a secret string of random numbers that can be used to encrypt communications. The researchers beamed photons from the satellite to Earth over distances of up to 1,200 kilometers, using the photons’ polarization, the orientation of their electromagnetic waves, to transmit a string of random numbers with utmost security.

Quantum communication via satellite can reach greater distances than land-based transmission, because in space, particles don’t get absorbed by the atmosphere. The new results pave the way for a global quantum internet that would provide for ultrasecure communications and allow quantum computers to work together.

Common drugs help reverse signs of fetal alcohol syndrome in rats

A common blood sugar medication or an extra dose of a thyroid hormone can reverse signs of cognitive damage in rats exposed in utero to alcohol. Both affect an enzyme that controls memory-related genes in the hippocampus, researchers report July 18 in Molecular Psychiatry.

That insight might someday help scientists find an effective human treatment for fetal alcohol spectrum disorders, which can cause lifelong problems with concentration, learning and memory. “At this moment, there’s really no pharmaceutical therapy,” says R. Thomas Zoeller, a neurobiologist at the University of Massachusetts Amherst.
Fetal alcohol syndrome disorders may affect up to 5 percent of U.S. kids, according to estimates from the U.S. Centers for Disease Control and Prevention. Scientists don’t know exactly why alcohol has such a strong effect on developing brains. But the lower thyroid hormone levels commonly induced by alcohol exposure might be one explanation, suggests study coauthor Eva Redei, a psychiatrist at Northwestern University Feinberg School of Medicine in Chicago.

“The mother has to supply the thyroid hormones for brain development,” says Redei. So, pregnant women who drink might not be providing their fetuses with enough hormones for normal brain development. That could disrupt the developing hippocampus, a brain region involved in learning and memory.

To counter alcohol’s effects, Redei and her colleagues gave doses of thyroxine, a thyroid hormone, to newborn rats that had been exposed to alcohol before birth. (That timing coincides developmentally with the third trimester of pregnancy in humans.) The amount of alcohol fed to the rat moms corresponded roughly to a woman drinking a glass or two of wine a day.

The treatment helped, the team found. Healthy rats will freeze in place when they’re put in a room where they’ve previously experienced a mild electrical shock. Adult rats exposed to alcohol during development freeze for a shorter period of time, suggesting that they might not learn the association between the shock and the room as effectively. Thyroxine treatment after birth made rats freeze about 30 percent longer than rats that didn’t get the treatment — almost on par with rats born to nondrinking moms.

Surprisingly, treatment with a blood sugar drug called metformin also had a similar effect. While seemingly unrelated, the two treatments work in similar ways, Redei says. Alcohol makes the hippocampus produce less of an enzyme called Dnmt1. That enzyme regulates the way key learning and memory-related genes turn on and off during development. Disruptions in that process can harm hippocampus function. “Both treatments normalize those enzyme levels,” Redei says.
Whether this treatment will work in people is far from a guarantee: Many promising treatments shown in rats don’t pan out in humans. Plus, fetal alcohol syndrome includes a complex suite of physical, cognitive and behavioral symptoms, which probably aren’t all controlled by thyroid hormone levels.

“Kids with fetal alcohol effects don’t look like kids with congenital hypothyroidism,” a condition resulting in low thyroid hormone levels, says Zoeller. Alcohol exposure during development affects other systems, too, like the immune system.

Still, Redei eventually hopes to test thyroxine and metformin in pregnant drinkers during their third trimester to see if the drugs might improve their kids’ outcomes. (Both are generally recognized as safe for pregnant women at standard doses.)

If treatment works, it might be particularly helpful for women who drank heavily in their first trimester before realizing they were pregnant, says Joanne Rovet, who studies fetal alcohol syndrome at the Hospital for Sick Children in Toronto.

Readers question hominid family tree

Hominid hubbub
In “Hominid roots may go back to Europe” (SN: 6/24/17, p. 9), Bruce Bower reported that the teeth of Graecopithecus, a chimp-sized primate that lived in southeastern Europe 7 million years ago, suggest it was a member of the human evolutionary family.

“Is it appropriate to use the terms ‘hominid’ and ‘ape’ as if the two are mutually exclusive categories?” asked online reader Tim Cliffe. “The distinction being made is between our clade in particular and all other apes. It seems to me that ‘hominids’ should be described as a subset of apes, not a separate category,” he wrote.
“Yes, hominids are apes,” Bower says. “The terminology gets pretty thick in evolutionary studies, so researchers (and journalists) use some shortcuts.”

Fossils of many ancient apes dating to between 25 million and 5 million years ago have been found, but the interest in this case is in a key transition to a particular kind of ape that walked upright and displayed various skeletal traits similar to traits unique to the human evolutionary family. “That’s why one source in the story, Bernard Wood, wonders whether Graecopithecus was an apelike hominid or a hominid-like ape,” Bower says. “But it’s important to remember that hominids diverged from other, ancestral apes. So did chimps.”

Science News defines “hominid” as a member of the human evolutionary family.

Laser, camera, action
The world’s fastest video camera films 5 trillion frames every second, Ashley Yeager reported in “A different kind of camera captures speedy actions” (SN: 6/24/17, p. 5). The camera works by flashing a laser at a subject and using a computer program to combine the still images into a video. Researchers tested the device by filming particles of light as the particles traveled a short distance.

Online reader JHoughton1 wondered if the researchers really filmed a light particle in their tests. “I thought light ‘sometimes behaves like a wave, sometimes like a particle,’ but that there isn’t really any particle that’s a particle in the usual sense. Is this really a picture of a ‘particle’ of light? A photon-as-ball-of-stuff?”

The camera captured the forward progression of a laser pulse, which is an ensemble of photons, Yeager says.

Photons themselves aren’t “balls of stuff” on quantum scales, says physics writer Emily Conover. All particles, including photons, are spread out in space, propagating like waves. “Only when scientists measure or observe a photon or any other particle do they find it in one place, like the ball of stuff that people typically imagine. I think in that sense, photons are about as tangible as any other quantum particle,” Conover says.

Bringing down the mucus house
Little-known sea animals called giant larvaceans can catch a lot of carbon in disposable mucus casings called “houses,” Susan Milius reported in “ ‘Mucus houses’ catch sea carbon fast” (SN: 6/10/17, p. 13).

Online reader Robert Stenton wondered what happens to mucus houses as they fall to the bottom of the ocean.

What happens to discarded houses isn’t yet clear, Milius says, though researchers have proposed that the houses might carry substantial portions of carbon to life on the sea bottom. And if bits of a house fall fast enough to reach great depths, the carbon could get trapped in water masses that move around the planet for centuries before surfacing. Bits drifting down slowly may be intercepted by microbes and other debris feeders and would not end up sequestered.

Correction
In “Human noises invade wilderness” (SN: 6/10/17, p. 14), Science News incorrectly reported that official wilderness areas in the United States do not allow livestock grazing. Grazing is permitted in protected wilderness areas at preprotection levels under the Wilderness Act of 1964, which created the National Preservation System.

Newborn baby’s infection offers a cautionary tale about placenta pills

When I was pregnant, I spent a lot of time searching for good information about how to keep both my baby and myself healthy after birth. Googling “placenta” and “eat,” I got a list of stories that reached nearly opposite conclusions about the practice.

Some say eating the organ will replenish mom’s nutrients, increase breast milk production and even stave off postpartum depression. Others point out that there are no studies that report these benefits, and placenta eating comes with risks. Scientists and doctors still have a lot of unanswered questions about the safety of the practice.

Here’s one story new mothers considering eating their placenta might want to pay extra attention to: Oregon doctors suspect that contaminated placenta pills may have caused a dangerous infection in a newborn.

Just after birth, this newborn had trouble breathing. Tests revealed a blood infection with Group B Streptococcus, or GBS. These bacteria are found in about a quarter of healthy women’s nether regions and can pose a danger to newborns. The baby probably picked up a GBS infection while passing through the birth canal.

After a round of ampicillin, the baby went home healthy. But five days later, the baby was in trouble again. Doctors at a second hospital found more GBS in the blood. After another round of antibiotics, two types this time, the baby was again sent home.

Doctors at the second hospital learned that three days after the baby had been born, the mother had begun eating six placenta capsules daily. She had hired a company to clean, slice and dehydrate her placenta before grinding it up and putting it into pills. Lab tests found the exact same strain of GBS that had infected the baby in the placenta pills. Genevieve Buser and colleagues published the case details June 30 in the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Report.

Buser, a pediatric infectious disease physician at Providence Health System in Portland, Ore., says the situation represents the first time researchers have turned up harmful bacteria in encapsulated placenta. “But then, I don’t think that anyone has looked.”
The mother’s breast milk tested negative for GBS. GBS can live in both men and women, mainly in the digestive tract, anus, vagina and, occasionally, skin. The placenta pills could have been dosing the mother regularly with the bacteria, boosting bacterial loads on her skin and in her digestive tract. Through touching, those bacteria could have been transferred to the baby.

The fact that the same strain of bacteria was found in the pills and in the baby’s blood led the researchers to suspect that the pills — and the mother — were a likely source of the infection. Still, Buser cautions that the bacteria transfer from pills to mom to baby “can’t be proven in one case study.”

Other sources of infection exist: The mother could have been colonized in a different way, the bacteria could have come from another person, and the placenta pills could have been contaminated after they were made. “This case report raises more questions than it answers,” Buser says. “But that is good and what science and medicine are all about.”

The baby probably picked up the first GBS infection during birth. With all the excitement of a new baby, it’s easy to forget that the placenta also passed through the same birth canal, picking up the same bacteria that live there. And anyway, placentas aren’t sterile. They’re actually home to swarms of various microbes.

Bottom line, Buser says: “This is a human tissue that is not sterilized.” She points out that dehydrating meat, including placenta, isn’t enough to kill bacteria that can make people sick, including forms of E. coli and Salmonella. A snack texturally similar to placenta, dried deer jerky, sickened people in Oregon in 1995 with E. coli O157. In later lab tests, 10 hours of drying failed to kill that bacteria.

Placenta pills (and other placenta recipes) aren’t regulated, which means there’s no way to tell if the product is safe. Nor is there a foolproof way to spot potentially harmful infections in mothers. In this case, the mother tested negative for GBS at 37 weeks of her pregnancy. That was either a bad test or she acquired the infection after it. There were no signs that she — and ultimately, her placenta — was colonized by bacteria that may have been harmful to her baby.

In their report, Buser and her colleagues don’t mince words: “The placenta encapsulation process does not per se eradicate infectious pathogens; thus, placenta capsule ingestion should be avoided.” If a mother still wants to eat her placenta, she ought to tell her care providers, Buser says. That way, they’ll be aware of the possible risks.